Bioactive Small Molecules
Cayman Chemical N-Peptide (trifluoroacetate salt), Purity: ≥95%, 5 mg
An E. coli SurA-binding protein; binds to the E. coli periplasmic molecular chaperone SurA (Kds = 2.3 and 1.69 µM for the full-length protein and core domain, respectively)
Cayman Chemical SD-06, Purity: ≥98%, CAS: 271576-80-8, 25 mg
An inhibitor of p38α MAPK (IC50 = 0.016 µM); selective for p38α over p38β, p38γ, and p38δ MAPKs (IC50s = 0.677, >100, and >100 µM, respectively), as well as a panel of 54 additional kinases (IC50s = >3 µM for all); inhibits LPS-induced TNF-α, IL-6, and IL-1β release from primary human monocytes (IC50s = 79.4, 106.9, and 105.9 nM, respectively); decreases IL-1β-induced production of PGE2 in patient-derived RASFs (IC50 = 96.2 nM); reduces carrageenan-induced paw swelling and hyperalgesia in rats at 30 mg/kg; reduces the incidence of arthritis in a mouse model of collagen-induced arthritis; protects against joint and bone destruction in a rat model of streptococcal cell wall-induced arthritis
Medchemexpress LLC HY-101283 5mg Medchemexpress, HCH6-1 CAS:1435265-06-7 Purity:>98%
Medchemexpress, HY-101283 5mg HCH6-1 CAS:1435265-06-7 HCH6-1 is a competitive antagonist of Formyl peptide receptor 1 (FPR1), an emerging therapeutic target for the discovery of drugs to treat neutrophilic inflammatory diseases. HCH6-1 is a selective FPR1 inhibitor and has protective effects against acute lung injury (ALI). HCH6-1 inhibits superoxide anion generation, elastase release, and chemotaxis in human neutrophils activated by fMLF (an FPR1 agonist). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Androsin, Purity: ≥98%, CAS: 531-28-2, 5 mg
A phenol glucoside with diverse biological activities; active against the bacteria S. aureus, S. epidermidis, P. aeruginosa, E. cloacae, K. pneumoniae, and E. coli (MICs = 0.6-1.08 mg/ml) and the fungi C. albicans, C. tropicalis, and C. glabrata (MICs = 1.85, 1.7, and 1.65 mg/ml, respectively); inhibits bronchial obstruction in guinea pig model of asthma induced by ovalbumin or PAF at 10 mg/kg
Medchemexpress LLC Glucosylceramidase (GBA) protein, human (HEK293), His-tagged | >95.0% | 10 UG
Recombinant human glucosylceramidase (GBA) produced in HEK293 cells with a C-terminal His tag. The enzyme hydrolyzes glucosylceramide to ceramide and glucose and is supplied in a small-scale format intended for biochemical assays and antibody validation.
- Recombinant human enzyme expressed in HEK293 cells.
- C-terminal His tag for detection and purification.
- High purity (>95% by reducing SDS-PAGE).
- Glycosylated protein, apparent molecular weight ~60-80 kDa.
- Supplied as a small-scale quantity suitable for assay development.
- Suitable for enzymatic assays, antibody validation, and lysosomal biology studies.
Cayman Chemical N-Pyrrolidino Fluetonitazene (citrate), Purity: ≥98%, 5 mg
An analytical reference standard that is structurally similar to known opioids; intended for research and forensic applications
Cayman Chemical SAG 21k, Purity: ≥98%, CAS: 946002-48-8, 10 mg
An agonist of the hedgehog signaling pathway; activates Smo in a reporter assay using C3H/10T1/2 cells expressing Smo (EC50 = 0.3 nM); increases the levels of mRNA encoding Ki67, Ccdc1, collagen II, ALP, Gli1, and Gli2 and decreases the levels of mRNA encoding MMP-13 in mouse primary chondrocytes at 1 nM; induces the formation of bone calluses and partial bone unions and increases total bone volume, but not total tissue volume, in a mouse model of surgery-induced non-healing bone fracture at 5 mg/kg per day
Medchemexpress LLC BMS 466442 | 1598424-76-0 | 99.0% | 100 MG
BMS-466442 is a potent, selective inhibitor of the Asc-1 (alanine serine cysteine transporter-1) used in neuroscience research and in vitro transporter assays. It is supplied as a high-purity powder with characterized solubility and storage recommendations.
- Potent asc-1 inhibitor with reported IC50 ~11 nM
- Inhibits [3H] D-serine uptake in rat synaptosomes (IC50 ~400 nM)
- Purity reported as 98.99%
- Molecular weight 538.59 g/mol; formula C31H30N4O5
- Soluble in DMSO at 100 mg/mL (185.67 mM)
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month)
Cayman Chemical 4-chloro-α-Pyrrolidinoisohexanophenone (hydrochloride), Purity: ≥98%, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical A-867744, Purity: ≥98%, CAS: 1000279-69-5, 10 mg
A positive allosteric modulator of α7 nAChRs; selective for α7 nAChRs over α3β2- and α4β2 subunit-containing nAChRs (IC50s = 0.023, 19.5 and 6.4 µM, respectively) and 5-HT3A receptors (Ki = >30 µM); potentiates ACh-induced currents in Xenopus oocytes expressing human α7 nAChRs (EC50 = ~1 µM); improves sensory gating deficits in a paired auditory stimulus paradigm in mice from 0.1-10 μmol/kg, i.p.
Medchemexpress LLC PD-1 Mouse HEK293 500ug
Recombinant mouse PD-1 extracellular domain fused to an Fc tag, expressed in HEK293 cells and supplied as a purified protein for immunology research. It is intended for use in assays that require a biologically relevant, mammalian-expressed PD-1 reagent, such as binding studies and receptor-ligand interaction experiments.
- Mammalian expression supports native folding and glycosylation.
- Fc fusion enhances stability and promotes dimerization.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Low endotoxin level (<1 EU/μg) suitable for sensitive assays.
- Available in a 500 μg format for scaling experiments.
- Stable when aliquoted and stored at -20°C or -80°C for long-term use.
Cayman Chemical RG3039, Purity: ≥98%, CAS: 1005504-62-0, 25 mg
A DcpS inhibitor (IC50 = 0.069 nM); prevents denervation of the NMJ and decreases in NMJ synaptic transmission and myofiber size of the longissimus muscle in a mouse model of Smn1 knockout-induced SMA at 10 mg/kg; improves survival and motor function in the same model
STEMCELL Technologies Chaetocin, Size: 500 µg
Chaetocin is a fungal mycotoxin, originally produced by Chaetomium species, that inhibits the lysine-specific histone methyltransferases (HMTs) SU(VAR)3-9 (IC₅₀ = 0.8 μM). HMTs are responsible for methylation of histones, thereby affecting heterochromatinization. Chaetocin is also known to inhibit G9a and DIM5 (IC₅₀ = 2.5 μM and 3 μM respectively; Cherblanc et al.; Greiner et al.). Chaetocin also acts as a competitive substrate and inhibitor of the central oxidative stress remediation enzyme thioredoxin reductase-1 (TrxR1; Km = 4.6 μM) more potently than glutathione reductase or thioredoxin (Tibodeau et al.).CANCER RESEARCH· Induces cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells (Isham et al.; Spannhoff et al.)· Attenuates the growth of glioma xenografts accompanied by an increase in reactive oxygen species (ROS) production (Dixit et al.).
AdipoGen Emodin (250 mg)
Chemical. CAS: 518-82-1. Formula: C15H10O5. MW: 270.2. Isolated from Polygonum cuspidatum. p56lck protein kinase inhibitor. Competitive casein kinase II (CK2) inhibitor. Anticancer agent with apoptosis inducing with antiangiogenic activity. Antioxidant, vasorelaxant and neuroprotective agent. NF-kappaB activation inhibitor. Inflammasome inhibitor. Potent selective 11beta-HSD1 inhibitor. Improves insulin sensitivity and lipid metabolism. Estrogen receptor ERalpha and ERbeta inhibitor. Inhibits androgen receptor (AR) nuclear translocation and induces AR degradation. VEGFR2, FGFR-1, EGFR, PDGFR-beta and Kit inhibitor. JAK2 inhibitor. Anti-diabetic agent. AMPK activator and PPARgamma agonist. Adipogenesis inhibitor. P2X7 receptor antagonist. Wnt signaling & PI3K/Akt/GSK-3beta pathway modulator.
AdipoGen Hesperidin (100 g)
Chemical. CAS: 520-26-3. Formula: C28H34O15. MW: 610.56. Isolated from plant source. Hesperidin is a flavanone rutinoside first isolated from citrus peels. It is metabolized by intestinal bacteria to an aglycone form, hesperetin, which is thought to be more bioavailable due to reduced polarity that allows for increased cell permeability. Both hesperidin (Hsd) and its aglycone hesperetin (Hst) have various biological properties. Studies have shown both anti-cancer and cancer chemopreventive effects, associated with their antioxidant, radical scavenging and anti-inflammatory activities. In addition, Hsd and Hst interfere at different stages of cancer. They inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, Bcl-2 and Bax for the induction of apoptosis, and COX-2, MMP-2 and MMP-9 for the inhibition of angiogenesis and metastasis. They also have show cardioprotective, neuroprotective and antimicrobial effects.